Think HBR


Dr Vanessa Murphy and Professor Joerg Mattes 2
Researchers from the Hunter Medical Research Institute have demonstrated that a personalised management approach to pregnant women’s asthma can almost halve the rates of the development of childhood asthma.
Professor Joerg Mattes, Director of the University of Newcastle’s Priority Research Centre Grow Up Well, says that one of the holy grails of asthma research is to demonstrate that childhood asthma can be prevented. “If we can demonstrate that you can intervene and it can lead to the prevention of asthma, it’s exciting because prevention is better than a treatment.”
In this recent study, researchers followed up on the asthma status of pre-school aged children born to asthmatic mothers who had participated in the Managing Asthma in Pregnancy (MAP) trial undertaken in collaboration with the John Hunter Children’s Hospital. In that trial, one group was randomly allocated a traditional asthma-management approach while the other used a personalised approach by measuring a lunginflammation marker and tailored treatment to the mother’s lung inflammation and symptoms.
“With this new approach, pregnant women were on preventers earlier, and it was adjusted according to the levels of inflammation in the lungs,” Professor Mattes explained.
“When we followed up on these children four to six years later we found that the rates of childhood asthma were very much reduced.”
One of the most common childhood illnesses, asthma impacts children’s quality of life, leaving them more susceptible to growth delays and at higher risk of developing learning disabilities. In Australia, over 37,000 hospitalisations per annum are due to asthma, with children aged 0 -14 hospitalised at a significantly higher rate. Asthma can also be deadly if it is uncontrolled, with up to 400 deaths per year in Australia attributed to asthma.
Breathing For Life respiratory researcher Dr Vanessa Murphy’s research goal is to eliminate asthma. “Asthma is very unpredictable in pregnancy and we know that women who have poorly controlled asthma are more likely to have children who will develop asthma,” Dr Murphy said.
“What we’ve found is that when women’s asthma is controlled optimally by adjusting medication according to lung inflammation, is that we’re potentially preventing bronchiolitis in babies, and reducing the rate of asthma in pre-schoolers who are susceptible,” Dr Murphy explained.
It supports the benefits of regular inhaled steroid asthma preventer therapy during pregnancy for those women who need it for their asthma control instead of not taking the medication because of pregnancy. “It’s better for the mother, and for the baby, to take the medications that are needed to have optimal asthma control,” Professor Mattes concluded.